Biomonitoring for Occupational Exposure to Diisocyanates: A Systematic Review26.04.2020
IOM co-authors Biomonitoring for Occupational Exposure to Diisocyanates paper published in Annals of Work Exposures and Health.
Bernice Scholten, Laura Kenny, Radu-Corneliu Duca, Anjoeka Pronk, Tiina Santonen, Karen S Galea, Miranda Loh, Katriina Huumonen, Anne Sleeuwenhoek, Matteo Creta, Lode Godderis, Kate Jones,
Diisocyanates are a group of chemicals that are widely used in occupational settings. They are known to induce various health effects, including skin- and respiratory tract sensitization resulting in allergic dermatitis and asthma. Exposure to diisocyanates has been studied in the past decades by using different types of biomonitoring markers and matrices. The aim of this review as part of the HBM4EU project was to assess: (i) which biomarkers and matrices have been used for biomonitoring diisocyanates and what are their strengths and limitations; (ii) what are (current) biomonitoring levels of the major diisocyanates (and metabolites) in workers; and (iii) to characterize potential research gaps.