Use of the spinning disk technique to produce monodisperse microspheres of human serum albumin for labelling with radioisotopes

A commercially available Spinning Disk Aerosol Generator has been used to produce monodisperse microspheres of Human Serum Albumin in the size ranges suitable for lung perfusion and ventilation studies. The technique of generation used is especially useful where a variable range of particle sizes is required for routine experimental investigations; a simple method for denaturing and subsequent radioisotopic labelling of the microspheres is described