NANOREG 11 Deliverable D3.8 Improved and validated occupational exposure models of release, exposure, dispersion and transfer

Inhalation exposure modelling is extensively used in regulatory exposure assessment for
chemical agents. A number of exposure tools have been developed and recommended for use
under REACH, including screening tools such as ECETOC TRA1
, MEASE2
, and EMKG-EXPO3
and
higher tier tools such as Stoffenmanager4
and the Advanced REACH Tool5
(ART) (ECHA, 2016)
In addition, tools are becoming available that focus specifically on exposure to manufactured
nanomaterials (MNMs). These cover relatively crude control banding tools such as the CB
NanoTool as well as more advanced exposure/risk assessment tools such as Nanosafer and
Stoffenmanager -NANO for occupational exposures and ConsExpo-nano for consumer exposure.
However, most of these tools do not provide quantitative estimates of exposure.
It is important that quantitative models become available to assist with quantitative risk
assessment. In addition, it is critical that all models used for predicting exposure have a sound
scientific basis, are reliable and are validated and/or calibrated with high quality measurement
results.
To address some of these issues the objectives of Task 3.4 of the NANoREG project were
defined initially in the description of work (DOW) as follows:
a. To evaluate and compare existing exposure models and tools using data already collected as
well as data collected as part of the NANoREG project
b. To modify and adapt existing models and develop new models and tools as necessary
c. To re-evaluate and promulgate these new models
d. To use these models to develop effective control banding approaches