Integrated exposure for risk assessment in indoor environments, INTERA – Example: The dimethyl fumarate (DMF) case study

The INTERA project developed an online accessible, full-chain modelling platform,
incorporating tools and databases for indoor chemical source release, exposure and risk
assessment. It includes four modules (i) emissions to concentrations (air, dust), (ii)
concentrations to exposures (inhalation, ingestion and dermal), (iii) internal dosimetry
(generic PBPK) and (iv) uncertainty and variability (Markov chain Monte Carlo), is linked on
one hand to a data library and knowledge management system, and on the other to a results
visualisation platform. It was tested in three case studies with different chemicals (dimethyl
fumarate (DMF), BTEX and phthalates), different and multiple exposure routes, different
input and validation data availability. Preliminary results have already demonstrated its
capabilities: usefulness (risk prediction for DMF); coverage (exposure to whole body dose to
target organ metabolite dose and interaction for BTEX); and validity (agreement with
respective field data for phthalates).