A note on proteases and oxidants in injury to alveolar epithelial cells caused by lung – derived neutrophils in vitro.

This contribution concerns leucocyte-mediated injury in the alveolar region of the lung. Inflammatory leucocytes accumulate in this region in a range of chronic and acute conditions [1]. Whilst undoubtedly performing a defensive function in normal inflammatory responses within the lung, persistent or extensive accumulation of activated leucocytes within the fragile structure of the lung parenchyma is associated with damage to the alveolar septa which may be mediated by leucocyte products [2]. The outcome of this damage may be either fibroplasia within the septal interstitium or destruction of septa [1].